Grand Theft Auto V's takings are reported to have topped $6bn (£4.2bn) – more than double the highest-grossing films ever.
The video game, which is set in the fictional state of San Andreas, came out in September 2013 but remains popular following the release of downloadable content packs.
Its takings have outstripped the revenue made by any of the highest-grossing films, books or music albums ever released.
Even taking into account DVD and streaming sales of huge blockbusters such as the Star Wars franchise, Grand Theft Auto V still comes out on top.
"Since its launch in 2013, GTA V has sold 90 million units, putting its total haul for publisher Take-Two Interactive in the neighbourhood of $6 billion," Doug Creutz, an analyst for Cowen told MarketWatch.
The game, which was created by British developer Rockstar North, broke industry records when it was released, earning $800m (£560m) in its first day and $1bn (£700m) in the first three days.
"Videogames are a much better business than [movie] studios," said KeyBanc analyst Evan Wingren told Marketwatch.
"Games in general have the enviable position that their content is interactive, which allows them to make data-driven insights and adjust games and business models that benefits players and the company."
GTA V has been criticised for its violent content and portrayal of women.
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The story revolves around three criminals who plan heists, with many missions involving shooting and driving.
It can be played on PS3, Xbox 360, PS4, Xbox One and PC.